Manufactured by Janssen-Cilag
Uses: Complex partial. As an add-on can be used for tonic-clonics and Lennox Gastaut
Common side effects: Drowsiness, dizziness, insomnia, vomiting and weight loss
Remarks: Children with diabetes should be closely monitored
Product Info:
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Topiramate Product Information (pdf)
FURTHER READING
1. A RANDOMIZED, PLACEBO-CONTROLLED STUDY OF TOPIRAMATE IN PRIMARY GENERALIZED TONIC-CLONIC SEIZURES - V. Biton et al., Neurology 1999 52: 1330
2. COGNITIVE EFFECTS OF TOPIRAMATE, GABAPENTIN, AND LAMOTRIGINE IN HEALTHY YOUNG ADULTS - R. Martin et al., Neurology 1999 52: 321
3. A DOUBLE-BLIND, RANDOMIZED TRIAL OF TOPIRAMATE IN LENNOX-GASTAUT SYNDROME - R. C. Sachdeo et al., Neurology 1999 52: 1882
4. A DOUBLE-BLIND, RANDOMIZED TRIAL OF TOPIRAMATE AS ADJUNCTIVE THERAPY FOR PARTIAL-ONSET SEIZURES IN CHILDREN - R. D. Elterman et al., Neurology 1999 52: 1338
5. TOPIRAMATE INCREASES BRAIN GABA, HOMOCARNOSINE, AND PYRROLIINONE IN PATIENTS WITH EPILEPSY - A.Ognen et al., Neurology 1999 52: 473
6. TOPIRAMATE THERAPY OF EPILEPSY ASSOCIATED WITH ANGELMAN'S SYNDROME - David Neal Franz et al., Neurology 2000 54: 1185-1188
7. A DOUBLE-BLIND RANDOMIZED TRIAL OF TOPIRAMATE IN LENNOX-GASTAUT SYNDROME - R.C Sachdeo et al., Neurology., 52:1882-1887 1999
8. TOPIRAMATE IN LENNOX-GASTAUT SYNDROME: OPEN-LABEL TREATMENT OF PATIENTS COMPLETING A RANDOMIZED CONTROLLED TRIAL - T.A Glauser et al., Epilepsia., 41:S86-S90 2000
9. TOPIRAMATE MONOTHERAPY FOR PARTIAL ONSET SEIZURES - R.C Sachdeo et al., Epilepsia., 38:294-300 1997
10. A TRIAL OF TOPIRAMATE AS ADJUNCTIVE THERAPY IN CHILDREN WITH PARTIAL ONSET SEIZURES - R. Elterman et al., Neurology., 52:1338-1344 1999
11. TOPIRAMATE - T.A Glauser., Semin Ped Neurol., 4:34-42 1997
12. ANTICONVULSANT ACTIVITIES AND PROPERTIES OF TOPIRAMATE - K. Kimishima et al., Japan J Pharmacol., 58 (suppl. 1):211
13. SAFETY OF TOPIRAMATE: ADVERSE EVENTS AND RELATIONSHIP TO DOSING - S.D Shorvon., Epilepsia., 37 (suppl.2):S18-S22 1996
14. TOPIRAMATE USE IN PEDIATRIC PATIENTS - T.A Glauser., Can J Neurol Sci., 25:S8-S12 1998
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