Manufactured by Sanofi-Winthrop
Uses: Complex partial, Tonic-clonic, Absence
Common side effects: Indigestion, nausea, vomiting, drowsiness
Remarks: Valproate may increase the effects of benzodiazepines such as Diazepam. Carbamazepine, Phenobarbital, Phenytoin, and Primidone may decrease the effects of valproic acid. Sodium Valproate acutely inhibits Lamotrigine metabolism.
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FURTHER READING
1. LAMOTRIGINE VALPROATE COMEDICATION IN REFRACTORY PARTIAL SEIZURES: A REPORT OF SIX CASES - Pisani F et al., Epilepsia,1993,34(suppl.2),159
2. DIABLING TREMOR AFTER LAMOTRIGINE WITH SODIUM VALPROATE - Reutens DC et al.,Lancet, 1993,342(8864),17 July,185-186
3. INTERACTION OF LAMOTRIGINE WITH SODIUM VALPROATE - Pisani F et al.,Lancet, 1993,341(8854),8 May,1224
4. SODIUM VALPROATE ACUTELY INHIBITS LAMOTRIGINE METABOLISM - Yuen AWC et al., Br.J.Clin.Pharmacol.,1992,35(5),May,511-513
5. THERAPEUTIC INTERACTION OF LAMOTRIGINE AND SODIUM VALPROATE IN INTRACTABLE MYOCLONIC EPILEPSY - Ferrie CD et al., Seizure,1994,3(2),June,157-159
6. CUTANEOUS RASH WITH LAMOTRIGINE AND CONCOMITANT VALPROATE THERAPY - Russo M et al., Epilepsia,1994,35(suppl.7)72
7. INTERACTION OF LAMOTRIGINE WITH SODIUM VALPROATE - Panayiotopoulos CP et al.,Lancet,1993,341(8842),13 Feb.,445
8. EFFECT OF VALPROATE ON THE PHARMACOKINETICS OF LAMOTRIGINE (LAMICTAL) AT STEADY STATE - Yau MK et al., Epilepsia,1992,33(Suppl.3)82
9. SODIUM VALPROATE INHIBITS LAMOTRIGINE METABOLISM - Yuen AWC et al., Fundam.Clin.Pharmacol.,1991,5(5),468
10. EFFECT OF LAMOTRIGINE (LTG, LAMICTAL) ON THE PHARMACOKINECTICS AND BIOTRANSFORMATION OF VALPROATE - Anderson GD et al., Epilepsia,1992,33(Suppl.3)82
11. INCREASE OF PRE EXISTING TREMOR DURING TREATMENT WITH LAMOTRIGINE AND VALPROIC ACID: TWO CASES REPORTS - Mazza S et al.,Nuova Riv.Neurol.,1995,5(4),Aug.,151-152
12. EFFECTS OF LAMOTRIGINE VALPROATE COMEDICATION ON SEIZURE FREQUENCY AND UPPER LIMB TREMOR: A PHARMACODYNAMIC INTERACTION? - Pisani F et al., Epilepsia,1995,36(Suppl.3)S264
13. ALLERGIC SKIN RASH WITH LAMOTRIGINE AND CONCOMITANT VALPROATE THERAPY: EVIDENCE FOR AN INCREASED RISK - Li LM et al., Arq.Neuropsiquiatr.,1996,54(1),47-49
14. VALPROIC ACID: INTERACTIONS WITH OTHER DRUGS - Scheyer RD et al., in Antiepileptic Drugs, 4th ed., Ed.Levy RH et al., Raven Press 1995
15. PHOTOSENSITIVITY RELATED TO VALPROATE WITHDRAWL - G.Ambrosetto et al., Neurol. Neurosurg. Psychiatry, 50:1709-1710, 1987
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17. MONOTHERAPY WITH VALPROATE IN PRIMARY GENERALIZED EPILEPSIES - B.F.D Bourgeois et al., Epilepsia, 28(suppl.2):S8-S11 1987
18. VALPROATE IN THE TREATMENT OF ABSENCE EPILEPSY IN CHILDREN - G. Braathen et al., Epilepsia., 29:548-552 1988
19. VALPROATE TOXICITY - J.K Brown, Dev. Med. Child Neurol., 30:121-125 1988
20. LACK OF INTERACTION OF GABAPENTIN WITH CARBAMAZEPINE AND VALPROATE - L.L Radulovic et al., Epilepsia, 35:155-161 1994
21. COGNITIVE EFFECTS OF LONG TERM TREATMENT WITH PHENOBARBITAL AND VALPROIC ACID IN SCHOOL CHILDREN - E.P Calandre et al., Eur. Neurol., 81:504-506 1990
22. COMPARATIVE STUDY OF ETHOSUXIMIDE AND SODIUM VALPROATE IN THE TREATMENT OF TYPICAL ABSENCE SEIZURES (PETIT MAL) - N. Callaghan., Dev. Med. Child Neurol., 24:830-836 1982
23. VALPROATE MONOTHERAPY IN THE MANAGEMENT OF GENERALIZED AND PARTIAL SEIZURES - D.W Chadwick., Epilepsia., 28 (suppl.2):S12-S17 1987
24. SODUM VALPROATE: MONOTHERAPY AND POLYTHERAPY - A. Covanis et al., Epilepsia, 23:693-720 1982
25. ONCE DAILY SODIUM VALPROATE IN THE TREATMENT OF EPILEPSY - A. Covanis et al., Dev. Med. Child Neurol., 22:202-204 1980
26. VALPROATE MONOTHERAPY IN 30 PATIENTS WITH PARTIAL SEIZURES - J.C Dean et al., Epilepsia, 29:140-144 1988
27. WEIGHT GAIN DURING TREATMENT WITH VALPROATE - H. Dinesen et al., Acta Neurol. Scand., 70:65-69 1984
28. VALPROIC ACID HEPATIC FATALITIES: A RETROSPECTIVE REVIEW - F.E Driefuss et al., Neurology, 37:379-385 1987
29. SODIUM VALPROATE MONOTHERAPY IN CHILDHOOD EPILEPSY - O. Dulac et al., Brain Dev., 8:47-52 1986
30. DISCONTINUATION OF PHENYTOIN, CARBAMAZEPINE AND VALPROATE IN PATIENTS WITH ACTIVE EPILEPSY - J.S Duncan et al., Epilepsia, 31:324-333 1990
31. THE EFFECTS OF VALPROATE, CARBAMAZEPINE, AND OXCARBAZEPINE ON GROWTH AND SEXUAL MATURATION IN GIRLS WITH EPILEPSY - Johanna Rättyä et al., Pediatrics 1999 103: 588-593
32. VALPROATE THERAPY DOES NOT DEPLETE CARNITINE LEVELS IN OTHERWISE HEALTHY CHILDREN - Shinichi Hirose et al., Pediatrics 1998 101: e9
33. INTRAVENOUS VALPROIC ACID FOR MYOCLONIC STATUS EPILEPTICUS - Raj D. Sheth et al., Neurology 2000 54: 1201
34. ADDING VALPROATE TO LAMOTRIGINE: A STUDY OF THEIR PHARMACOKINETIC INTERACTION - Andres M. Kanner et al., Neurology 2000 55: 588-591
35. EXPERIMENTAL STUDIES AND CONTROLLED CLINICAL TESTING OF VALPROATE AND VIGABATRIN - L. Gram., Acta Neurol. Scand., 78:241-270 1988
36. COGNITIVE IMPAIRMENT IN NEW CASES OF EPILEPSY RANDOMLY ASSIGNED TO CARBAMAZEPINE, PHENYTOIN AND SODIUM VALPROATE - I. Forsythe et al., Dev. Med. Child Neurol., 33:524-536 1991
37. VALPROATE - L. Gram., In: Comprehensive Epileptology edited by M.Dam et al., Raven Press 1990
38. CLINICAL SIDE EFFECTS OF PHENOBARBITAL, PRIMIDONE, PHENYTOIN, CARBAMAZEPINE, AND VALPROATE DURING MONOTHERAPY IN CHILDREN - J.L Herrnaz et al., Epilepsia, 29:794-804 1988
39. PHARMACOKINETICS OF TOTAL AND FREE VALPROIC ACID DURING MONOTHERAPY IN INFANTS - L. Herngren et al., J. Neurol. 238:315-319 1991
40. PHARMACOKINETICS OF FREE AND TOTAL SODIUM VALPROATE IN ADOLESCENTS AND YOUNG ADULTS DURING MAINTENANCE THERAPY - L. Herngren et al., J. Neurol. 235:491-495 1988
41. EXPANDED THERAPEUTIC RANGE OF VALPROATE - D.L Hurst., Pediatr. Neurol., 3:342-344 1987
42. VITAMIN B6 AND VALPROIC ACID IN THE TREATMENT OF INFANTILE SPASMS - M. Ito et al., Pediatr. Neurol., 7:91-96 1991
43. SODIUM VALPROATE IN TREATMENT OF EPILEPSY - P.M Jeavons et al., Brit. Med. J., 2:584-586 1974
44. VALPROATE TREMORS - B.J Kaplan et al., Neurology 32:428-432 1982
45. VALPROIC ACID PHARMACOKINETICS IN CHILDREN: III. VERY HIGH DOSAGE REQUIREMENTS - R.L Kriel et al., Pediatr. Neurol., 2:202-208 1986
46. COMPARISONS BETWEEN CARBAMAZEPINE AND VALPROATE FOR COMPLEX PARTIAL AND SECONDARY GENERALIZED TONIC-CLONIC SEIZURES - R.H Mattson et al., Epilepsia., 42:18 1991
47. VALPROATE AND CLONAZEPAM COMEDICATION IN PATIENTS WITH INTRACTABLE EPILEPSY - R. Mireles et al., Epilepsia, 26:122-126 1985
48. TREATMENT OF INTRACTABLE CHILDHOOD EPILEPSY WITH HIGH-DOSE VALPROPATE - Y. Ohtsuka et al., Epilepsia., 33:158-164 1992
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