Manufactured by GlaxoWellcome
Uses: Complex partial, Tonic-clonic, Simple partial, Lennox-Gastaut, Absence
Common side effects: Headaches, dizziness, nausea, double vision and skin rash
Remarks: Sodium Valproate acutely inhibits Lamotrigine metabolism
Product Info:
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FURTHER READING
1. DRUGS IN FOCUS: 10. LAMOTRIGINE - MJ Brodie, Prescribers J.,1993(%), 212-216
2. LAMOTRIGINE IN CHILDHOOD REFRACTORY EPILEPSY: AN OPEN TRIAL - Coppola G et al, Boll.Lega Ital. Epilepsia, 1993, (84), 257-258
3. LAMOTRIGINE: MANAGING THE CHALLENGING PATIENT - Besag FMC, Seizure, 1994, 3(sup.A), Dec., 53-58
4. LAMOTRIGINE: A NOVEL APPROACH - Meldrum BS, Seizure, 1994, 3(sup.A), Dec., 41-45
5. LAMOTRIGINE: A CLINICAL OVERVIEW - Wallace SJ, Seizure, 1994, 3(sup.A), Dec., 47-51
6. GUIDELINE FOR TREATING EPILEPSY IN THE AGE OF FELBAMATE, VIGABATRIN, LAMOTRIGINE AND GABAPENTIN - Laxer KD, West.J.Med., 1994, 161, 309-314
7. LEUCOPENIA ASSOCIATED WITH LAMOTRIGINE - Nicholoson RJ et al, BMJ, 1995, 310(6978), 25 Feb., 504
8. THE EFFICACY AND LONG TERM TOLERABILITY OF LAMOTRIGINE IN THE TREATMENT OF SEVERE EPILEPSY - Sander JWAS et al, Epilepsy Res., 1990,7,226-229
9. LAMOTRIGINE - Burstein AH, Pharmacotherapy, 1995,15(2),129-143
10. DOUBLE BLIND, PLACEBO CONTROLLED, CROSSOVER STUDY OF LAMOTRIGINE IN TREATMENT RESISTANT PARTIAL SEIZURES - Schapel Gj et al, J. Neurol.Neuroosurg.Psychiatry, 1993,56(5),448-453
11.THE EFFICACY OF LAMOTRIGINE ON SEIZURE CONTROL IN 34 CHILDREN ADOLESCENTS AND YOUNG ADULTS WITH INTELLECTUAL AND PHYSICAL DISABILITY - Buchanan N, Seizure,1995,4(3),233-236
12. LAMOTRIGINE FOR THE TREATMENT OF EPILEPSY IN CHILDHOOD - Besag FMC et al, J.Pediatr.1995,127(6),991-997
13. INFLUENCE OF CONCURRENT ANTIEPILEPTIC MEDICATION ON THE PHARMACOKINETICS OF LAMOTRIGINE AS ADD ON THERAPY IN EPILEPTIC CHILDREN - Vauzelle-Kerroedan F et al, Br.J.Clin.Pharmacol.,1996,41(4),325-330
14. THREE YEAR EFFICACY AND TOLERABILITY OF ADD ON LAMOTRIGINE IN TREATMENT RESISTANT EPILEPTIC CHILDREN - Herranz JL et al, Clin.Drug Invest.,1996,11(4).,214-223
15. CLINICAL PHARMACOKINETICS OF NEWER ANTIEPILEPTIC DRUGS: LAMOTRIGINE, VIGABATRIN, GABAPENTIN AND OXCARABAZEPINE - Elwes RDC et al., Clin.Pharmacokinet.,1996,30(6), June,403-415
16. PHARMACOKINETICS OF LAMOTRIGINE IN YOUNG EPILEPTIC CHILDREN - Pons G et al., Epilepsia,1993,34(suppl.2),160
17. EFFICACY OF LAMOTRIGINE AS MONOTHERAPY FOR JUVENILE MYOCLONIC EPILEPSY: PILOT STUDY RESULTS - Timmings PL et al., Epilepsia,1993,34(suppl.2),160
18. LAMOTRIGINE VALPROATE COMEDICATION IN REFRACTORY PARTIAL SEIZURES: A REPORT OF SIX CASES - Pisani F et al., Epilepsia,1993,34(suppl.2),159
19. DIABLING TREMOR AFTER LAMOTRIGINE WITH SODIUM VALPROATE - Reutens DC et al.,Lancet, 1993,342(8864),17 July,185-186
20. INTERACTION OF LAMOTRIGINE WITH SODIUM VALPROATE - Pisani F et al.,Lancet, 1993,341(8854),8 May,1224
21. LAMOTRIGINE AS AN ADD ON DRUG IN THE MANAGEMENT OF LENNOX GASTAUT SYNDROME - Timmings PL et al.,Eur.Neurol.1992,32(6),305-307
22. SODIUM VALPROATE ACUTELY INHIBITS LAMOTRIGINE METABOLISM - Yuen AWC et al., Br.J.Clin.Pharmacol.,1992,35(5),May,511-513
23. THERAPEUTIC INTERACTION OF LAMOTRIGINE AND SODIUM VALPROATE IN INTRACTABLE MYOCLONIC EPILEPSY - Ferrie CD et al., Seizure,1994,3(2),June,157-159
24. CUTANEOUS RASH WITH LAMOTRIGINE AND CONCOMITANT VALPROATE THERAPY - Russo M et al., Epilepsia,1994,35(suppl.7)72
25. USING LAMOTRIGINE TO FULL ADVANTAGE - Besag FMC, Epilepsia,1994,35(suppl.7)71
26. CASE OF SEVERE ACUTE INTOXICATION WITH OXCARBAZEPINE COMBINED WITH LAMOTRIGINE - Alving J, Epilepsia,1994,35(suppl.7)72
27. LAMOTRIGINE IN INFANTILE SPASMSE - Veggiotti P et al.,Lancet,1994,344(8933),12 Nov.,1375-1376
28. LAMOTRIGINE EFFECT IN TYPICAL ABSENCES - Strumia S et al., Epilepsia,1994,35(suppl.8)118
29. OPEN MULTICENTRE TRIAL OF LAMOTRIGINE IN PATIENTS WITH TREATMENT RESISTANT EPILEPSY WITHDRAWING FROM ADD ON TO LAMOTRIGINE MONOTHERAPY - Clifford JS et al., Epilepsia,1994,35(suppl.8)31
30. SYNERGISTIC EFFECT OF LAMOTRIGINE VALPROATE COMEDICATION IN PATIENTS WITH REFRACTORY EPILEPSY - Pisani F et al.,Boll.Lega Ital.Epilepssia,1993,(82-83),147-148
31. OPEN MULTICENTER TRIAL OF LAMICTAL (LAMOTRIGINE) IN PATIENTS WITH TREATMENT RESISTANT EPILEPSY WITHDRAWING FROM ADD ON TO LAMICTAL MONOTHERAPY - Brodie MJ et al., Epilepsia,1994,35(suppl.7)69-70
32. INTERACTION OF LAMOTRIGINE WITH SODIUM VALPROATE - Panayiotopoulos CP et al.,Lancet,1993,341(8842),13 Feb.,445
33. PRELIMANARY DATA FROM AN OPEN MULTICENTER TRIAL OF LAMOTRIGINE (LAMICTAL) IN PATIENTS WITH TREATMENT RESISTANT EPILEPSY ON ONE ANTIEPILEPTIC DRUG WITHDRAWING MONOTHERAPY - Davies G et al., Epilepsia,1992,33(suppl.3)81
34. LAMOTRIGINE IN TREATMENT OF 120 CHILDREN WITH EPILEPSY - Schlumberger E et al., Epilepsia,1994,35(2)359-367
35. EFFECT OF VALPROATE ON THE PHARMACOKINETICS OF LAMOTRIGINE (LAMICTAL) AT STEADY STATE - Yau MK et al., Epilepsia,1992,33(Suppl.3)82
36. LAMOTRIGINE: PRELIMINARY CLINICAL OBSERVATIONS ON PHARMACOKINECTICS AND INTERACTIONS WITH TRADITIONAL ANTIEPILEPTIC DRUGS - Wolf P.,J.Epilepsy,1992,5(2),73-79
37. LAMOTRIGINE AS AN ADD ON DRUG IN TYPICAL ABSENCE SEIZURES - Ferrie CD et al., Acta Neurol.Scand.,1995,91(3),200-202
38. SODIUM VALPROATE INHIBITS LAMOTRIGINE METABOLISM - Yuen AWC et al., Fundam.Clin.Pharmacol.,1991,5(5),468
39. DOUBLE BLIND CROSSOVER TRIAL OF LAMOTRIGINE (LAMICTAL) AS ADD ON THERAPY IN INTRACTABLE EPILEPSY - Binnie CD et al., Epilepsy Res.,1989,4,222-229
40. A RANDOMISED DOUBLE BLIND PLACEBO CONTROLLED ADD ON TRIAL OF LAMOTRIGINE IN PATIENTS WITH SEVERE EPILEPSY - Sander JWAS et al., Epilepsy Res.,1990,6,221-226
41. LAMOTRIGINE - Messenheimer JA., Epilepsia,1995,36(Suppl.2)S87-S94
42. THROMBOCYTOPENIA AND RASH UNDER ADD ON THERAPY WITH LAMOTRIGINE AND SODIUM VALPROATE IN A 15 YEAR OLD GIRL WITH LENNOX GASTAUT SYNDROME - Langler A et al., Aktuel.Neurol.,1995,22(2),66-67
43. EFFECT OF LAMOTRIGINE (LTG, LAMICTAL) ON THE PHARMACOKINECTICS AND BIOTRANSFORMATION OF VALPROATE - Anderson GD et al., Epilepsia,1992,33(Suppl.3)82
44. INCREASE OF PRE EXISTING TREMOR DURING TREATMENT WITH LAMOTRIGINE AND VALPROIC ACID: TWO CASES REPORTS - Mazza S et al.,Nuova Riv.Neurol.,1995,5(4),Aug.,151-152
45. EFFECTS OF LAMOTRIGINE VALPROATE COMEDICATION ON SEIZURE FREQUENCY AND UPPER LIMB TREMOR: A PHARMACODYNAMIC INTERACTION? - Pisani F et al., Epilepsia,1995,36(Suppl.3)S264
46. LAMOTRIGINE ENCEPHALOPATHY - Hennessy MJ et al., Lancet,1996,347(9006),6 Apr.,974-975
47. ALLERGIC SKIN RASH WITH LAMOTRIGINE AND CONCOMITANT VALPROATE THERAPY: EVIDENCE FOR AN INCREASED RISK - Li LM et al., Arq.Neuropsiquiatr.,1996,54(1),47-49
48. THE USE OF LAMOTRIGINE IN JUVENILE MYOCLONIC EPILEPSY - Buchanan N., Seizure,1996,5(2),149-151
49. LAMOTRIGINE: SINGLE DOSE PHARMACOKINECTICS AND INITIAL 1 WEEK EXPERIENCE IN REFRACTORY EPILEPSY - Jawad S et al., Epilepsy Res.,1987,1(3)194-201
50. ACUTE EFFECTS OF LAMOTRIGINE (BW430C) IN PERSONS WITH EPILEPSY - Binnie CD et al., Epilepsia,1986,27(3),248-254
51. LAMOTRIGINE - M.J Brodie, Lancet, 339:1397-1400 1992
52. CONTROLLED TRIAL OF LAMOTRIGINE (LAMICTAL) FOR REFRACTORY PARTIAL SEIZURES - S. Jawad et al., Epilepsia, 30:356-63, 1989
53. LAMOTRIGINE: A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND CLINICAL EFFICACY IN EPILEPSY - K.L Goa et al., Drugs, 46:152-176 1993
54. DIFFERENTIAL COGNITIVE AND BEHAVIORAL EFFECTS OF CARBAMAZEPINE AND LAMOTRIGINE - K. J. Meador et al., Neurology 2001 56: 1177-1182
55. A PLACEBO-CONTROLLED TRIAL OF LAMOTRIGINE ADD-ON THERAPY FOR PARTIAL SEIZURES IN CHILDREN - M. Duchowny et al., Neurology 1999 53: 1724
56. COGNITIVE EFFECTS OF TOPIRAMATE, GABAPENTIN, AND LAMOTRIGINE IN HEATHY YOUNG ADULTS - R. Martin et al., Neurology 1999 52: 321
57. ADDING VALPROATE TO LAMOTRIGINE: A STUDY OF THEIR PHARMACOKINETIC INTERACTION - Andres M. Kanner et al., Neurology 2000 55: 588-591
58. EXACERBATION OF JUVENILE MYOCLONIC EPILEPSY WITH LAMOTRIGINE - Enrique J. Carrazana et al., Neurology 2001 56: 1424-a-1425-a
59. EXACERBATION OF JUVENILE MYOCLONIC EPILEPSY WITH LAMOTRIGINE - A. Biraben et al., Neurology 2000 55: 1757-1758
60. AN ACTIVE-CONTROL TRIAL OF LAMOTRIGINE MONOTHERAPY FOR PARTIAL SEIZURES - C. P. Panayiotopoulos et al., Neurology 2000 54: 777
61. POTENTIAL ANTIEPILEPTIC DRUGS: LAMOTRIGINE - L. Gram., In: Antiepileptic Drugs, 3rd Edition edited by R. Levy et al.,., Raven Press 1989
62. LAMOTRIGINE AS AN ADD-ON DRUG IN THE MANAGEMENT OF LENNOX-GASTAUT SYNDROME - P.L Timmings et al., Eur. Neurol., 32:305-307 1992
63. LAMOTRIGINE IN THE TREATMENT OF 120 CHILDREN WITH EPILEPSY - E. Schlumberger et al., Epilepsia., 35:359-367 1994
64. INTRACTABLE EPILEPSY IN CHILDREN. THE EFFICACY OF LAMOTRIGINE TREATMENT, INCLUDING NON-SEIZURE RELATED BENEFITS - P. Uvebrant et al., Neuropediatrics., 25:284-289 1994
65. LAMOTRIGINE: CLINICAL EXPERIENCE IN 93 PATIENTS WITH EPILEPSY - N. Buchanan., Acta Neurol Scand., 92:28-32 1995
66. THE EFFICACY OF LAMOTRIGINE IN CHILDREN AND ADOLESCENTS WITH REFRACTORY GENERALIZED EPILEPSY: A RANDOMIZED, DOUBLE-BLIND, CROSSOVER STUDY - A.S Eriksson et al., Epilepsia., 39:495-501 1998
67. LAMOTRIGINE FOR GENERALIZED SEIZURES ASSOCIATED WITH LENNOX-GASTAUT SYNDROME - J. Motte et al., N. Engl. J. Med., 337:1807-1812 1997
68. OVERVIEW OF LAMOTRIGINE AND THE NEW ANTIEPILEPTIC DRUGS: THE CHALLENGE - J.M Pellock., J. Child Neurol., 12:S48-S52 1997
69. LAMOTRIGINE INDUCED SEVERE CUTANEOUS ADVERSE REACTIONS - R.G Schienger et al., Epilepsia., 39:S22-S26 1998
70. LAMOTRIGINE - F. Matsuo., Epilepsia., 40:S30-S36 1999
71. LAMICTAL (LAMOTRIGINE) MONOTHERAPY FOR TYPICAL ABSENCE SEIZURES IN CHILDREN - L.M Frank et al., Epilepsia., 40:973-979 1999
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